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Young Rebecca’s life isn’t always easy. Besides having to get used to her parents’ separation, her fragile immune system means that she frequently falls ill. One day, she catches a new virus that will turn her life upside-down. The virus in question calls itself Ernest, and it is able to talk and to transform itself at will. Ernest and Rebecca will become best friends, and together they will face the problems that confront the little girl. Between playing pranks on the doctors and trying to get Rebecca’s parents back together, they have their work cut out for them !